Ethylparaben or Ethyl Paraben Ph Eur USP NF BP Grade Manufacturers

Anmol Chemicals is the pioneer manufacturers of Ethylparaben or Ethyl Paraben or Ethyl para-Hydroxybenzoate, Pharmaceutical Excipients Fragrance & Flavor chemicals in India. We offer Halal and Kosher Ethylparaben or Ethyl Paraben or Ethyl para-Hydroxybenzoate made in an ISO9001, ISO22000 (FSSC22000) and cGMP GLP certified facility. Our group has several manufacturing facilities spread across the world, supported by toll manufacturers and representatives in UAE, Europe, Africa, USA, China and has several associated manufacturing facilities spread across India. All the Information on Physics, Chemistry, Applications, Uses and Technology on Manufacture of Ethylparaben or Ethyl Paraben or Ethyl para-Hydroxybenzoate is in these pages.

The units have one or more of the certifications like FDA GMP, ISO 9001, ISO 22000, HACCP, REACH, Kosher & Halal

Ethylparaben or Ethyl Paraben or Ethyl para-Hydroxybenzoate Ph Eur USP NF BP Grade Manufacturers

CAS Number: 120-47-8, EINECS EC Number: 204-399-4, Molecular Formula: C9H10O3, Molecular Weight: 166.18

Parabens are a class of widely used preservatives in cosmetic and pharmaceutical products. They are found in shampoos, commercial moisturizers, shaving gels, personal lubricants, topical/parenteral pharmaceuticals, suntan products, makeup, and toothpaste. They are also used as food additives. Parabens are active against a broad spectrum of microorganisms.

Ethylparaben (ethyl para-hydroxybenzoate) is the ethyl ester of p-hydroxybenzoic acid. Its formula is HO-C6H4-CO-O-CH2CH3. It is used as an antifungal preservative. As a food additive, it has E number E214. Sodium ethyl para-hydroxybenzoate, the sodium salt of ethylparaben, has the same uses and is given the E number E215.

Ethyl Hydroxybenzoate BP Grade Specifications
Ethyl paraben
Ethyl Parahydroxybenzoate, Ph Eur
C9H10O3 --- 166.2 --- 120-47-8

DEFINITION
Ethyl 4-hydroxybenzoate.
Content: 98.0 per cent to 102.0 per cent.

CHARACTERS
Appearance: White or almost white, crystalline powder or colourless crystals.
Solubility: Very slightly soluble in water, freely soluble in alcohol and in methanol.

IDENTIFICATION
First identification A, B.
Second identification A, C, D.
A. Melting point 115C to 118C.
B. Infrared absorption spectrophotometry. Comparison ethyl parahydroxybenzoate CRS.
C. Examine the chromatograms obtained in the test for related substances.
Results: The principal spot in the chromatogram obtained with test solution (b) is similar in position and size to the principal spot in the chromatogram obtained with reference solution (b).
D. To about 10 mg in a test-tube add 1 ml of sodium carbonate solution, boil for 30 s and cool (solution A). To a further 10 mg in a similar test-tube add 1 ml of sodium carbonate solution; the substance partly dissolves (solution B). Add at the same time to solution A and solution B 5 ml of aminopyrazolone solution and 1 ml of potassium ferricyanide solution and mix. Solution B is yellow to orange-brown. Solution A is orange to red, the colour being clearly more intense than any similar colour which may be obtained with solution B.

TESTS
Solution S: Dissolve 1.0 g in alcohol and dilute to 10 ml with the same solvent.
Appearance of solution: Solution S is clear and not more intensely coloured than reference solution.
Acidity: To 2 ml of solution S add 3 ml of alcohol, 5 ml of carbon dioxide-free water and 0.1 ml of bromocresol green solution. Not more than 0.1 ml of 0.1 M sodium hydroxide is required to change the colour of the indicator to blue.
Related substances: To pass the test (0.5 per cent).
Sulphated ash: Maximum 0.1 per cent, determined on 1.0 g.

IMPURITIES
A. R = H: 4-hydroxybenzoic acid,
B. R = CH3: methyl 4-hydroxybenzoate,
C. R = CH2-CH2-CH3: propyl 4-hydroxybenzoate,
D. R = CH2-CH2-CH2-CH3: butyl 4-hydroxybenzoate.

Ethylparaben USP NF Grade Specifications
C9H10O3 --- 166.17
Benzoic acid, 4-hydroxy-, ethyl ester.
Ethyl p-hydroxybenzoate [120-47-8].
Ethylparaben contains not less than 98.0 percent and not more than 102.0 percent of C9H10O3.

Identification:
A: Infrared Absorption 197M .
B: Melting range: between 115Cand 118C.
Color of solution: Dissolve 1 g in alcohol, dilute with alcohol to 10 mL, and mix (Ethylparaben solution). This solution is clear and not more intensely colored than alcohol or a solution prepared immediately before use by mixing 2.4 mL of ferric chloride CS, 1.0 mL of cobaltous chloride, and 0.4 mL of cupric sulfate with 0.3 N hydrochloric acid to make 10 mL, and diluting 5 mL of this solution with 0.3 N hydrochloric acid to make 100 mL. Make the comparison by viewing the solutions downward in matched color-comparison tubes against a white surface.
Acidity: To 2 mL of Ethylparaben solution prepared in the Color of solution test add 3 mL of alcohol, 5 mL of carbon dioxide-free water, and 0.1 mL of bromocresol green, and titrate with 0.10 N sodium hydroxide: not more than 0.1 mL is required to produce a blue color.
Residue on ignition: not more than 0.1%, determined on 1.0 g.
Related substances: To pass the test.

Ethylparaben or Ethyl Paraben or Ethyl para-Hydroxybenzoate Ph Eur USP NF BP Grade manufacturers at:

Anmol Chemicals
S-8, SARIFA MANSION, 2ND FLANK ROAD, CHINCHBUNDER, MUMBAI 400009, INDIA
TEL: (OFFICE) 91-22-23770100, 23726950, 23774610, 23723564. FAX: 91-22-23728264

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